Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28196417 | 0.79 | TSHR (0.65) | TSHRGPR35NPC1POLBGAA | |
| SCHEMBL16212526 | 0.77 | TSHR (0.63) | TSHRGPR35NPC1POLBGAA | |
| SCHEMBL18490191 | 0.77 | TSHR (0.63) | TSHRGPR35DAOGSK3BCHEK1 | |
| SCHEMBL673307 | 0.74 | TSHR (0.59) | TSHRNPC1POLBGAARAB9A | |
| SCHEMBL2745234 | 0.73 | NPC1 (0.59) | TSHRGPR35NPC1POLBGAA | |
| SCHEMBL9220569 | 0.71 | TSHR (0.56) | TSHRGPR35DAOGSK3BCES2 | |
| SCHEMBL12768622 | 0.71 | TSHR (0.55) | TSHRGPR35ALDH1A1ALOX15MAPT | |
| SCHEMBL20607404 | 0.69 | TSHR (0.52) | TSHRGPR35DAOGSK3BCHEK1 | |
| SCHEMBL623033 | 0.68 | TSHR (0.52) | TSHRGPR35DAOGSK3BALAD | |
| SCHEMBL852028 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |