SCHEMBL6733848

SCHEMBL6733848

O=C(/C=C/c1ccc([N+](=O)[O-])cc1)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.85

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.85
MAOA P21397 5/20 0.85
BCHE P06276 1/20 0.84
CYP1B1 Q16678 1/20 0.84
HSPD1 P10809 1/20 0.75
HSPE1 P61604 1/20 0.75
CTSL P07711 1/20 0.72
CTSB P07858 1/20 0.72
ALDH1A1 P00352 1/20 0.67
LMNA P02545 1/20 0.67
MAPT P10636 1/20 0.67
PTPN1 P18031 2/20 0.66
KRAS P01116 2/20 0.63
PTPN12 Q05209 1/20 0.62
PTPN22 Q9Y2R2 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6733854 1.00 MAOB (0.85) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL8977012 0.94 MAOB (0.76) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL8965792 0.94 MAOB (0.76) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL9136940 0.94 MAOB (0.80) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL8965786 0.94 MAOB (0.76) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL9136943 0.94 MAOB (0.80) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL8977005 0.94 MAOB (0.76) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL3041716 0.92 MAOB (0.74) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL9137109 0.92 MAOB (0.74) MAOBMAOABCHECYP1B1HSPD1
SCHEMBL3052864 0.92 MAOB (0.74) MAOBMAOABCHECYP1B1HSPD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119318957-A For synthesizing photosensitivity catalyst for diamine compound 青岛伯川特聚科技有限公司 2025-01-17 CN disclosed
US-20040110757-A1 Flt-1 ligands and their uses in the treatment of diseases regulatable by angiogenesis ARRHENIUS THOMAS (US) 2004-06-10 US disclosed
EP-1370250-A2 FLT-1 LIGANDS AND THEIR USES IN THE TREATMENT OF DISEASES REGULATABLE BY ANGIOGENESIS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-12-17 EP disclosed
US-20030065039-A1 Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones STATENS SERUM INSTITUTE (DK) 2003-04-03 US disclosed
WO-2002076438-A2 FLT-1 LIGANDS AND THEIR USES IN THE TREATMENT OF DISEASES REGULATABLE BY ANGIOGENESIS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-10-03 WO disclosed
EP-0996432-A2 BIOLOGICALLY ACTIVE 1,3-BIS-AROMATIC-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIC-PROPAN-1-ONES, AND 1,3-BIS-AROMATIC-PROP-2-YN-1-ONES STATENS SERUMINSTITUT (DK) 2000-05-03 EP disclosed
WO-1999000114-A2 BIOLOGICALLY ACTIVE 1,3-BIS-AROMATIC-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIC-PROPAN-1-ONES, AND 1,3-BIS-AROMATIC-PROP-2-YN-1-ONES STATENS SERUM INSTITUT (DK) 1999-01-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030065039-A1 Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones AKR1C3, AKR1C1, AKR1A1 MAOB 943/4885MAOA 904/4885BCHE 3521/4885
US-20040110757-A1 Flt-1 ligands and their uses in the treatment of diseases regulatable by angiogenesis FLT1, FLT4, TEK MAOB 744/4885MAOA 1200/4885BCHE 3669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.