Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 18/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422175 | 0.88 | GRM2 (0.76) | GRM2CYP3A4 | |
| SCHEMBL6727470 | 0.86 | GRM2 (0.73) | GRM2 | |
| SCHEMBL6738265 | 0.86 | GRM2 (1.00) | GRM2CYP3A4 | |
| SCHEMBL6731879 | 0.85 | GRM2 (0.62) | GRM2 | |
| SCHEMBL10560111 | 0.84 | GRM2 (0.74) | GRM2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL6738229 | 0.84 | GRM2 (0.74) | GRM2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL6739402 | 0.84 | GRM2 (0.74) | GRM2CYP3A4CHRNB2CHRNA4 | |
| SCHEMBL6727546 | 0.83 | GRM2 (0.77) | GRM2CYP3A4 | |
| SCHEMBL6727449 | 0.82 | GRM2 (0.64) | GRM2CYP3A4 | |
| SCHEMBL6739466 | 0.82 | GRM2 (0.78) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800651-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-10-05 | — | — | US | disclosed |
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | disclosed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | GRM2 3/4885CYP3A4 2786/4885CHRNB2 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.