Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT2 | P23786 | 1/20 | 0.58 |
| ▸ | CPT1A | P50416 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | CRAT | P43155 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734056 | 0.94 | CPT2 (0.58) | CPT2CPT1ACA4CA2CTSL | |
| SCHEMBL11666499 | 0.80 | — | — | |
| SCHEMBL7466938 | 0.80 | CPT2 (0.52) | CPT2CPT1ACA4CA2CTSL | |
| SCHEMBL4868828 | 0.80 | CPT2 (0.52) | CPT2CPT1ACA4CA2CTSL | |
| Aspartic Acid SCHEMBL1655126 | 0.77 | CA4 (0.48) | CPT2CPT1ACA4CA2CTSL | |
| SCHEMBL3036426 | 0.76 | CPT2 (0.54) | CPT2CPT1ACA4CA2CTSL | |
| SCHEMBL4343361 | 0.76 | CPT2 (0.54) | CPT2CPT1ACA4CA2CTSL | |
| SCHEMBL4892256 | 0.76 | CPT2 (0.48) | CPT2CPT1ACA4CA2CTSL | |
| SCHEMBL3691259 | 0.75 | CPT2 (1.00) | CPT2CPT1ASLC22A16CRATMEN1 | |
| SCHEMBL7097510 | 0.75 | CPT2 (1.00) | CPT2CPT1ASLC22A16CRATMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686133-B2 | CONTAINING LIGHT-INSENSITIVE SILVER SALTS OF ORGANIC CARBOXYLIC ACIDS WITH ONE OR MORE CARBOXYLIC ACID AND A BINDER, EXCLUSIVE OF SILVER SUCCINATE SIMILAR COMPOUNDS | AGFA-GEVAERT (BE) | 2004-02-03 | — | — | US | disclosed |