Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | IDE | P14735 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HLCS | P50747 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 8/20 | 0.44 |
| ▸ | CA1 | P00915 | 8/20 | 0.44 |
| ▸ | CA2 | P00918 | 8/20 | 0.44 |
| ▸ | CA9 | Q16790 | 8/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL15067661 | 1.00 | TDP1 (0.62) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL20495575 | 1.00 | TDP1 (0.62) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL29349497 | 0.89 | TDP1 (0.53) | TDP1MEN1ABL1LMNAPKM | |
| Histidine SCHEMBL2269187 | 0.86 | TDP1 (0.62) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL10612975 | 0.86 | TDP1 (0.65) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL30081014 | 0.83 | TDP1 (0.53) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8366189 | 0.82 | TDP1 (0.68) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL15067659 | 0.82 | TDP1 (0.62) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL5903513 | 0.81 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL8011738 | 0.81 | TDP1 (0.77) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040185530-A1 | Novel thermophilic polymerase III holoenzyme | REPLIDYNE, INC. | 2004-09-23 | — | — | US | disclosed |
| US-6677146-B1 | HAVING AT LEAST 95% IDENTITY TO AMINO ACID SEQUENCE 10; STIMULATING PROCESSIVE DNA REPLICATION | REPLIDYNE, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1268813-A2 | THERMOPHILIC POLYMERASE III HOLOENZYME | McHenry, Charles S. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001073052-A2 | THERMOPHILIC POLYMERASE III HOLOENZYME | REPLIDYNE, INC. (US) | 2001-10-04 | — | — | WO | disclosed |