SCHEMBL6734811

SCHEMBL6734811

O=C(C1CN=C(c2ccncc2)NC1)N1CCN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1

nearest known ligand 0.65

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.65
ATM Q13315 1/20 0.48
CNR1 P21554 3/20 0.47
CHRM1 P11229 1/20 0.47
NPSR1 Q6W5P4 1/20 0.45
LMNA P02545 2/20 0.44
USP2 O75604 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
F2 P00734 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6729440 0.85 F10 (0.51) F10CNR1
SCHEMBL6730119 0.84 F10 (0.50) F10F2
SCHEMBL1387192 0.79 F10 (1.00) F10CNR1CHRM1LMNAUSP2
Hydrochloric Acid SCHEMBL6198874 0.79 F10 (0.67) F10ATMCNR1CHRM1NPSR1
Hydrochloric Acid SCHEMBL6198871 0.79 F10 (0.67) F10ATMCNR1CHRM1NPSR1
Hydrochloric Acid SCHEMBL6196960 0.78 F10 (0.75) F10ATMCNR1CHRM1NPSR1
Hydrochloric Acid SCHEMBL6196964 0.78 F10 (0.75) F10ATMCNR1CHRM1NPSR1
SCHEMBL4942386 0.77 F10 (0.70) F10CNR1NPSR1LMNAUSP2
SCHEMBL5193868 0.76 ATM (0.71) F10ATMLMNAF2
SCHEMBL6786578 0.76 F10 (0.94) F10CNR1CHRM1NPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 F10 19/4885ATM 2080/4885CNR1 162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.