Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 16/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 10/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | STK16 | O75716 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10125376 | 0.91 | PTK2 (0.44) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL15023795 | 0.86 | PTK2 (0.45) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL670549 | 0.83 | PTK2 (0.49) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL670533 | 0.75 | PTK2 (0.53) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL670009 | 0.74 | PTK2 (0.49) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL669481 | 0.74 | PTK2 (0.58) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL669800 | 0.71 | PTK2B (0.46) | PTK2PTK2BTBK1SRCGSK3A | |
| SCHEMBL15023735 | 0.71 | PTK2B (0.46) | PTK2PTK2BTBK1NEK2 | |
| SCHEMBL669843 | 0.71 | PTK2B (0.49) | PTK2PTK2BTBK1 | |
| SCHEMBL10125447 | 0.71 | PTK2 (0.58) | PTK2PTK2BTBK1SRCGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |
| EP-2606034-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | Merck Patent GmbH (DE) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022408-A1 | PYRIMIDINE DERIVATIVES AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |