Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | LTA4H | P09960 | 5/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125825 | 0.88 | NPC1 (0.49) | NPC1RAB9ALTA4HMCL1CHEK1 | |
| SCHEMBL28342834 | 0.82 | RAB9A (0.67) | NPC1RAB9ALTA4HMCL1CYP11B2 | |
| SCHEMBL3129027 | 0.81 | MCL1 (0.53) | NPC1RAB9AMCL1GLAHPGD | |
| SCHEMBL13996075 | 0.80 | MEN1 (0.62) | NPC1RAB9ACHEK1CYP11B2CYP11B1 | |
| SCHEMBL27875172 | 0.79 | CYP2C9 (0.57) | NPC1RAB9ALTA4HCYP11B2CYP11B1 | |
| SCHEMBL14801814 | 0.78 | MCL1 (0.71) | NPC1RAB9AMCL1XDHMEN1 | |
| SCHEMBL4995514 | 0.78 | HPGD (0.46) | NPC1RAB9ALTA4HCHEK1HPGD | |
| SCHEMBL21882397 | 0.76 | MCL1 (0.69) | NPC1RAB9AMCL1XDHMEN1 | |
| SCHEMBL21882451 | 0.76 | MCL1 (0.69) | NPC1RAB9AMCL1XDHMEN1 | |
| SCHEMBL13203160 | 0.76 | MCL1 (0.69) | NPC1RAB9AMCL1XDHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | CGI PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| WO-2004000820-A2 | CERTAIN AROMATIC MONOCYCLES AS KINASE MODULATORS | CELLULAR GENOMICS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | MAP3K20, MAP3K1, MAP3K19 | NPC1 3477/4885RAB9A 2270/4885LTA4H 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.