Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 3/20 | 0.46 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14109596 | 0.94 | CA2 (0.60) | CA2CA4SLC22A16CA1CTSL | |
| SCHEMBL11112367 | 0.94 | CA2 (0.60) | CA2CA4SLC22A16CA1CTSL | |
| SCHEMBL11112756 | 0.94 | CA2 (0.60) | CA2CA4SLC22A16CA1CTSL | |
| SCHEMBL10902049 | 0.94 | CA2 (0.68) | CA2CA4SLC22A16CA1CTSL | |
| SCHEMBL3911447 | 0.94 | CA2 (0.60) | CA2CA4SLC22A16CA1CTSL | |
| SCHEMBL6739831 | 0.94 | CA2 (0.60) | CA2CA4SLC22A16CA1CTSL | |
| 3-Methylbutanoic Acid SCHEMBL10565463 | 0.81 | — | — | |
| SCHEMBL28577685 | 0.80 | — | — | |
| Lithium Ion SCHEMBL11691728 | 0.80 | — | — | |
| SCHEMBL14698415 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686133-B2 | CONTAINING LIGHT-INSENSITIVE SILVER SALTS OF ORGANIC CARBOXYLIC ACIDS WITH ONE OR MORE CARBOXYLIC ACID AND A BINDER, EXCLUSIVE OF SILVER SUCCINATE SIMILAR COMPOUNDS | AGFA-GEVAERT (BE) | 2004-02-03 | — | — | US | claimed |
| US-20030064328-A1 | Photothermographic materials processable at lower temperatures and recording processes therefor | AGFA-GEVAERT (BE) | 2003-04-03 | — | — | US | claimed |
| EP-1258775-A2 | Photothermographic materials and recording processes therefor | AGFA-GEVAERT N.V. (BE) | 2002-11-20 | — | — | EP | claimed |
| EP-1246001-A1 | Thermographic materials and recording processes therefor | Agfa-Gevaert (BE) | 2002-10-02 | — | — | EP | claimed |
| US-6686133-B2 | CONTAINING LIGHT-INSENSITIVE SILVER SALTS OF ORGANIC CARBOXYLIC ACIDS WITH ONE OR MORE CARBOXYLIC ACID AND A BINDER, EXCLUSIVE OF SILVER SUCCINATE SIMILAR COMPOUNDS | AGFA-GEVAERT (BE) | 2004-02-03 | — | — | US | disclosed |
| US-20030064328-A1 | Photothermographic materials processable at lower temperatures and recording processes therefor | AGFA-GEVAERT (BE) | 2003-04-03 | — | — | US | disclosed |
| EP-1258775-A2 | Photothermographic materials and recording processes therefor | AGFA-GEVAERT N.V. (BE) | 2002-11-20 | — | — | EP | disclosed |
| EP-1246001-A1 | Thermographic materials and recording processes therefor | Agfa-Gevaert (BE) | 2002-10-02 | — | — | EP | disclosed |