Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNF4 | P78317 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727472 | 0.87 | RNF4 (0.53) | RNF4MMP13LMNACYP3A4HTT | |
| SCHEMBL6735689 | 0.86 | GRM2 (0.60) | RNF4MMP13LMNACYP3A4HTT | |
| SCHEMBL6732239 | 0.85 | RNF4 (0.57) | RNF4MMP13LMNACYP3A4HTT | |
| SCHEMBL6739479 | 0.84 | NPY5R (0.51) | RNF4MMP13LMNACYP3A4HTT | |
| SCHEMBL6738576 | 0.81 | MAPK14 (0.52) | RNF4HTTMAPK14SMN1; SMN2MEN1 | |
| SCHEMBL6732007 | 0.80 | HTT (0.49) | RNF4MMP13LMNACYP3A4HTT | |
| SCHEMBL1337080 | 0.79 | USP2 (0.60) | RNF4LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6003103 | 0.79 | NPC1 (0.57) | RNF4HTTSMN1; SMN2 | |
| SCHEMBL6727502 | 0.78 | LMNA (0.53) | RNF4MMP13LMNACYP3A4HTT | |
| SCHEMBL3064585 | 0.76 | GAA (0.51) | RNF4LMNANR3C1KDM4CTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | claimed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | RNF4 4707/4885MMP13 4756/4885LMNA 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.