SCHEMBL6739153

SCHEMBL6739153

[CH2]Cc1cc(C)c2ccccc2c1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 0.55
CYP2A6 P11509 4/20 0.55
ALDH1A1 P00352 5/20 0.45
HSD17B10 Q99714 2/20 0.40
HPGD P15428 2/20 0.40
APOBEC3A P31941 1/20 0.40
APOBEC3G Q9HC16 1/20 0.40
TYMP P19971 1/20 0.38
TSHR P16473 1/20 0.38
HIF1A Q16665 1/20 0.37
CYP1B1 Q16678 1/20 0.37
KDM4E B2RXH2 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HTR2A P28223 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
BACE1 P56817 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6367430 0.82 CYP1A2 (0.57) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL5898012 0.80 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL8851565 0.80 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL15345412 0.80 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL5898006 0.80 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL23465385 0.80 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL7653944 0.78 CYP1A2 (0.59) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL13476109 0.77 CYP2A6 (0.57) CYP1A2CYP2A6ALDH1A1APOBEC3AAPOBEC3G
SCHEMBL8852073 0.77 CYP1A2 (0.52) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD
SCHEMBL8852077 0.77 CYP2A6 (0.52) CYP1A2CYP2A6ALDH1A1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6689771-B2 TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-02-10 US disclosed
US-6376665-B1 ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-04-23 US disclosed
EP-1165500-A1 AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE Du Pont Pharmaceuticals Company (US) 2002-01-02 EP disclosed
WO-2000059874-A1 NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE DU PONT PHARMACEUTICALS COMPANY (US) 2000-10-12 WO disclosed