Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL20213749 | 0.96 | GRM8 (0.44) | MEN1KMT2AGRM8GRM6GRIN2D | |
| Racemethionine SCHEMBL23924542 | 0.95 | MEN1 (0.43) | MEN1KMT2ABHMTLMNABHMT2 | |
| Methionine SCHEMBL3091904 | 0.95 | MEN1 (0.43) | MEN1KMT2ABHMTLMNABHMT2 | |
| Methionine SCHEMBL4402781 | 0.95 | MEN1 (0.43) | MEN1KMT2ABHMTLMNABHMT2 | |
| Racemethionine SCHEMBL28765103 | 0.91 | MEN1 (0.41) | MEN1KMT2ABHMTLMNABHMT2 | |
| D-Glutamate SCHEMBL27622200 | 0.91 | GRM8 (0.50) | KMT2AGRM8GRM6GRIN2DGRIN3B | |
| Glutamic Acid SCHEMBL194964 | 0.91 | GRM8 (0.50) | KMT2AGRM8GRM6GRIN2DGRIN3B | |
| Methionine SCHEMBL4275752 | 0.91 | MEN1 (0.47) | MEN1KMT2ABHMTLMNABHMT2 | |
| Racemethionine SCHEMBL4275749 | 0.91 | MEN1 (0.47) | MEN1KMT2ABHMTLMNABHMT2 | |
| Racemethionine SCHEMBL23924535 | 0.91 | MEN1 (0.47) | MEN1KMT2ABHMTLMNABHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6682753-B2 | Methods for promoting weight gain using GPE-related compounds | NEURONZ LIMITED (NZ) | 2004-01-27 | — | — | US | disclosed |
| WO-2003086323-A2 | COMPOSITIONS AND METHODS FOR IMMUNOMODULATION | NEURONZ LIMITED (NZ) | 2003-10-23 | — | — | WO | disclosed |
| US-20020151522-A1 | Regulation of weight | ENDOCRINZ LIMITED (NZ) | 2002-10-17 | — | — | US | disclosed |