Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1123890 | 0.90 | KDM4E (0.51) | POLBLMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL1123978 | 0.90 | PIK3CB (0.54) | POLBLMNAHPGDHTTKDM4E | |
| SCHEMBL1123969 | 0.90 | KDM4E (0.51) | POLBLMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL1123911 | 0.90 | PIK3CB (0.54) | POLBLMNAHPGDHTTKDM4E | |
| SCHEMBL6036708 | 0.88 | ALDH1A1 (0.62) | POLBLMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL1123822 | 0.85 | PIK3CB (0.50) | POLBLMNAHPGDHTTKDM4E | |
| SCHEMBL1123887 | 0.85 | ALDH1A1 (0.53) | POLBLMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL1124073 | 0.84 | TSHR (0.50) | POLBLMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL1124234 | 0.83 | KMT2A (0.52) | POLBLMNAHPGDHTTKDM4E | |
| SCHEMBL1124057 | 0.83 | HSD17B10 (0.49) | POLBLMNAHPGDHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | CGI PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | claimed |
| WO-2004000820-A2 | CERTAIN AROMATIC MONOCYCLES AS KINASE MODULATORS | CELLULAR GENOMICS, INC. (US) | 2003-12-31 | — | — | WO | claimed |
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | CGI PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| WO-2004000820-A2 | CERTAIN AROMATIC MONOCYCLES AS KINASE MODULATORS | CELLULAR GENOMICS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | MAP3K20, MAP3K1, MAP3K19 | POLB 3482/4885LMNA 3782/4885HPGD 4061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.