Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.42 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 4/20 | 0.39 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156860 | 0.81 | AHR (0.39) | GRIA1CACNG8AHRCMA1EIF2AK2 | |
| SCHEMBL1436084 | 0.77 | GRIA1 (0.53) | PKMGRIA1CACNG8AHRCMA1 | |
| SCHEMBL6743543 | 0.77 | CRBN (0.51) | PKMGRIA1CACNG8AHRCMA1 | |
| SCHEMBL17120924 | 0.71 | AHR (0.53) | PKMGRIA1CACNG8AHRCMA1 | |
| SCHEMBL10368283 | 0.71 | GRIA1 (0.47) | PKMGRIA1CACNG8AHRCMA1 | |
| SCHEMBL152270 | 0.71 | AHR (0.53) | PKMGRIA1CACNG8AHREPHX2 | |
| SCHEMBL31010750 | 0.71 | AHR (0.59) | GRIA1CACNG8AHRCMA1EIF2AK2 | |
| SCHEMBL4976325 | 0.70 | GRIA1 (0.46) | PKMGRIA1CACNG8AHRCMA1 | |
| SCHEMBL15929644 | 0.68 | GRIA1 (0.47) | PKMGRIA1CACNG8AHRCMA1 | |
| SCHEMBL2486755 | 0.68 | GRIA1 (0.51) | PKMGRIA1CACNG8AHRCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |