Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.38 |
| ▸ | CMA1 | P23946 | 2/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL152807 | 0.84 | HDAC3 (0.45) | CRBNPOLBHDAC3AHRCMA1 | |
| SCHEMBL6358092 | 0.81 | SMYD3 (0.46) | CRBNPOLBAHRCMA1SMYD3 | |
| SCHEMBL6740903 | 0.77 | PKM (0.43) | CRBNPKMGRIA1CACNG8AHR | |
| SCHEMBL1436084 | 0.76 | GRIA1 (0.53) | CRBNPKMGRIA1CACNG8POLB | |
| SCHEMBL154971 | 0.74 | SMYD3 (0.60) | CRBNPOLBHDAC3AHRSMYD3 | |
| SCHEMBL3662896 | 0.74 | CRBN (0.52) | CRBNPOLBAHRCMA1SMYD3 | |
| SCHEMBL19031038 | 0.73 | CRBN (0.44) | CRBNGRIA1CACNG8AHRCMA1 | |
| SCHEMBL19031217 | 0.73 | CRBN (0.45) | CRBNGRIA1CACNG8AHRCMA1 | |
| SCHEMBL29819513 | 0.72 | ALDH1A1 (0.58) | POLBALDH1A1HPGDGAA | |
| SCHEMBL17120924 | 0.70 | AHR (0.53) | PKMGRIA1CACNG8AHRCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002540096-A | — | — | 2002-11-26 | — | — | JP | claimed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | claimed |
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |