Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 3/20 | 0.50 |
| ▸ | CMA1 | P23946 | 2/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057929 | 0.89 | PDE3B (0.60) | AHRCRBNPDE3BPDE3AMAPT | |
| SCHEMBL10779358 | 0.79 | MAPT (0.62) | CRBNPDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL6844435 | 0.75 | KDM1A (0.52) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL29899623 | 0.75 | KDM1A (0.55) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6744849 | 0.75 | KDM1A (0.55) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL29850050 | 0.75 | PDE3B (0.76) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6744175 | 0.75 | PDE3B (0.76) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6743078 | 0.75 | CRBN (0.52) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6744090 | 0.74 | KDM1A (0.51) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6742260 | 0.74 | KDM1A (0.54) | KDM1AAHRCMA1CRBNPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |