Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6740947 | 1.00 | CDK2 (0.49) | CDK2KDRCYP2A6PDPK1RET | |
| SCHEMBL6744866 | 0.81 | RET (0.59) | CDK2KDRCYP2A6PDPK1RET | |
| SCHEMBL6744863 | 0.81 | RET (0.59) | CDK2KDRCYP2A6PDPK1RET | |
| SCHEMBL6742680 | 0.78 | CDK2 (0.53) | CDK2KDRRETPLK4PLK1 | |
| SCHEMBL6742678 | 0.78 | CDK2 (0.53) | CDK2KDRRETPLK4PLK1 | |
| SCHEMBL5473028 | 0.76 | PDGFRB (0.57) | KDRPDPK1RETNPC1PLK4 | |
| SCHEMBL5473025 | 0.76 | PDGFRB (0.57) | KDRPDPK1RETNPC1PLK4 | |
| SCHEMBL6740553 | 0.71 | CDK2 (0.50) | CDK2KDRPDPK1RETALDH1A1 | |
| SCHEMBL6740554 | 0.71 | CDK2 (0.50) | CDK2KDRPDPK1RETALDH1A1 | |
| SCHEMBL6743049 | 0.70 | CDK2 (0.45) | CDK2KDRRETPLK4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002540096-A | — | — | 2002-11-26 | — | — | JP | claimed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | claimed |
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |