Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 4/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TPI1 | P60174 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742678 | 1.00 | CDK2 (0.53) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6740947 | 0.78 | CDK2 (0.49) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6740946 | 0.78 | CDK2 (0.49) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6744079 | 0.76 | GSK3B (0.57) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6744081 | 0.76 | GSK3B (0.57) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6740553 | 0.75 | CDK2 (0.50) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6740554 | 0.75 | CDK2 (0.50) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6743633 | 0.72 | CDK2 (0.48) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6743630 | 0.72 | CDK2 (0.48) | CDK2KDRRETPDGFRBEGFR | |
| SCHEMBL6743049 | 0.72 | CDK2 (0.45) | CDK2KDRRETEGFRPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002540096-A | — | — | 2002-11-26 | — | — | JP | claimed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | claimed |
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |