Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL163388 | 1.00 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29152424 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL4347204 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29152416 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29107242 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18981017 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250255887-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. | 2025-08-14 | — | — | US | claimed |
| EP-4521952-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | Balchem Corporation (US) | 2025-03-19 | — | — | EP | claimed |
| US-12128057-B2 | Dietary nutrient compositions | Natals, Inc. (US) | 2024-10-29 | — | — | US | claimed |
| US-12128056-B2 | Dietary nutrient compositions | Natals, Inc. (US) | 2024-10-29 | — | — | US | claimed |
| WO-2023220606-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORPORATION (US) | 2023-11-16 | — | — | WO | claimed |
| US-20230357280-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORPORATION | 2023-11-09 | — | — | US | claimed |
| US-20220305033-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. | 2022-09-29 | — | — | US | claimed |
| US-20220096499-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. | 2022-03-31 | — | — | US | claimed |
| CN-113679040-A | Solid beverage for improving insulin sensitivity of type II diabetes mellitus people | 上海英库商务咨询有限公司 | 2021-11-23 | — | — | CN | claimed |
| US-11083738-B2 | Dietary nutrient compositions | Natals, Inc. (US) | 2021-08-10 | — | — | US | claimed |
| WO-2019067924-A1 | DIETARY NUTRIENT COMPOSITIONS | Natals, Inc. (US) | 2019-04-04 | — | — | WO | claimed |
| US-20180280430-A1 | COMPOSITION FOR IMPROVED PERFORMANCE | BALCHEM CORPORATION | 2018-10-04 | — | — | US | claimed |
| EP-3355989-A1 | COMPOSITION FOR IMPROVED PERFORMANCE | Balchem Corporation (US) | 2018-08-08 | — | — | EP | claimed |
| US-8728535-B2 | Nutritional supplement for use under physiologically stressful conditions | VERTICAL PHARMACEUTICALS, LLC (US) | 2014-05-20 | — | — | US | claimed |
| US-20130004570-A1 | NUTRITIONAL SUPPLEMENT FOR USE UNDER PHYSIOLOGICALLY STRESSFUL CONDITIONS | VERTICAL PHARMACEUTICALS, INC. (US) | 2013-01-03 | — | — | US | claimed |
| US-8202546-B2 | Nutritional supplement for use under physiologically stressful conditions | VERTICAL PHARMACEUTICALS, INC. (US) | 2012-06-19 | — | — | US | claimed |
| US-20100136104-A1 | NUTRITIONAL SUPPLEMENT FOR USE UNDER PHYSIOLOGICALLY STRESSFUL CONDITIONS | CIBC BANK USA | 2010-06-03 | — | — | US | claimed |
| US-20100080856-A1 | Method and composition for postoperative wound healing | COSTANTINO PETER D | 2010-04-01 | — | — | US | claimed |
| US-12496289-B2 | Methods of increasing magnesium bioavailability and absorption | BALCHEM CORPORATION (US) | 2025-12-16 | — | — | US | disclosed |
| WO-1998033494-A1 | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF VASCULAR DEGENERATIVE DISEASES | KOSBAB JOHN V (US) | 1998-08-06 | — | — | WO | disclosed |