Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL674137 | 1.00 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29152424 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL4347204 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29152416 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29107242 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18981017 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1553 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026105164-A1 | NON-AQUEOUS LIQUID FORMULATIONS OF TETRACYCLINE ANTIBIOTICS | ETICO LIFESCIENCES PRIVATE LIMITED (IN) | 2026-05-21 | — | — | WO | claimed |
| CN-122030601-A | Composition of plant extract and akkermansia muciniphila and application of composition in improving intestinal health | 南京北极光生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4735008-A1 | IBOGAINE TREATMENT | Ambio Life Sciences Inc. (CA) | 2026-05-06 | — | — | EP | claimed |
| US-12582149-B1 | Functional additive for hot beverages and foods | MILJKOVIC IGOR (US) | 2026-03-24 | — | — | US | claimed |
| US-20260069910-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL SOLUTIONS AND METHODS OF AND APPARATUS FOR APPLYING THE SAME TO PROTECT PROPERTY AGAINST WILDFIRE | MIGHTY FIRE BREAKER LLC (US) | 2026-03-12 | — | — | US | claimed |
| US-20260069911-A1 | ENVIRONMENTALLY-CLEAN FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS AND POWDERS, AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD PRODUCTS | MIGHTY FIRE BREAKER LLC (US) | 2026-03-12 | — | — | US | claimed |
| US-20260048289-A1 | ENVIRONMENTALLY-SAFE WATER-BASED FIRE RETARDANT BIOCHEMICAL COMPOSITIONS FORMULATED USING ALKALI METAL SALTS, FREE FROM PHOSPHATES, NITRATES, AND AMMONIUM-SALTS, FOR NON-CORROSIVE AERIAL AND GROUND DELIVERY ONTO PROPERTY REQUIRING LONG-TERM PROTECTION AGAINST WILDFIRE | MIGHTY FIRE BREAKER LLC (US) | 2026-02-19 | — | — | US | claimed |
| US-20260034171-A1 | Composition for Improving Cognitive Function | PERRY STEPHEN C (US) | 2026-02-05 | — | — | US | claimed |
| US-12527813-B2 | Methods to stabilize and reverse atherosclerotic lesions by sulfated polysaccharides | CALROY HEALTH SCIENCES, LLC (US) | 2026-01-20 | — | — | US | claimed |
| US-20260014403-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS | MIGHTY FIRE BREAKER LLC (US) | 2026-01-15 | — | — | US | claimed |
| WO-2004075657-A2 | METHOD FOR REDUCING ACRYLAMIDE FORMATION IN THERMALLY PROCESSED FOODS | FRITO-LAY NORTH AMERICA, INC. (US) | 2004-09-10 | — | — | WO | claimed |
| US-20040058045-A1 | Method for reducing acrylamide formation in thermally processed foods | FRITO-LAY NORTH AMERICA, INC. | 2004-03-25 | — | — | US | claimed |
| US-20030211172-A1 | Composition and method for substantially reducing the deleterious effects of alcohol on the body | JONES JEREMY PARK (US) | 2003-11-13 | — | — | US | claimed |
| US-6589555-B2 | Effervescent vitaceutical compositions and related methods | PANDYA MAHENDRA (US) | 2003-07-08 | — | — | US | claimed |
| US-20030099724-A1 | Compounds for prevention of diabetic retinopathy | TURNER OLIVER E (US) | 2003-05-29 | — | — | US | claimed |
| US-6447809-B1 | MIXTURES OF MICROCRYSTALLINE HYDROXYAPATITE, CHOLECALCIFEROL AND IPRIFLAVONE ADMINISTERED AS OSTEOBLASTS STIMULANTS FOR PREVENTION OF OSTEOPOROSIS | METAGENICS, INC. | 2002-09-10 | — | — | US | claimed |
| US-20010051134-A1 | Effervescent vitaceutical compositions and related methods | PANDYA MAHENDRA (US) | 2001-12-13 | — | — | US | claimed |
| US-6042849-A | FOR TREATMENT OF CONDITIONS ASSOCIATED WITH THE CONSTRICTION OF SMALL BLOOD VESSELS SUCH AS ATHEROGENESIS, HEART ATTACK, STROKE, HYPERTENSION, GLAUCOMA, MIGRAINE, HYPERTENSION OF PREGNANCY, AND DIABETES MELLITUS | CHRONORX, LLC (US) | 2000-03-28 | — | — | US | claimed |
| US-5849338-A | Unit dosage forms for treatment of vasoconstriction and related conditions | CHRONORX LLC (US) | 1998-12-15 | — | — | US | claimed |
| WO-1997037670-A1 | UNIT DOSAGE FORMS, CONTAINING MAGNESIUM, VITAMIN C, VITAMIN E, FOLATE AND SELENIUM, FOR TREATMENT OF VASOCONSTRICTION AND RELATED CONDITIONS | CHRONORX, LLC (US) | 1997-10-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260034171-A1 | Composition for Improving Cognitive Function | PHOSPHO1, PSEN1, S100B | CA4 4082/4885CTSL 3149/4885CA2 1359/4885 |
| US-20260069910-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL SOLUTIONS AND METHODS OF AND APPARATUS FOR APPLYING THE SAME TO PROTECT PROPERTY AGAINST WILDFIRE | CA2, CA1, CA7 | CA4 10/4885CTSL 972/4885CA2 1/4885 |
| US-12582149-B1 | Functional additive for hot beverages and foods | SOD1, KCNN1, KCNN3 | CA4 192/4885CTSL 2868/4885CA2 6/4885 |
| US-12527813-B2 | Methods to stabilize and reverse atherosclerotic lesions by sulfated polysaccharides | RPS4Y1, PF4, PKD1 | CA4 693/4885CTSL 1873/4885CA2 2391/4885 |
| US-20260014403-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS | ME1, ATP6V1A, ATP5MF | CA4 47/4885CTSL 1340/4885CA2 12/4885 |
| US-20260048289-A1 | ENVIRONMENTALLY-SAFE WATER-BASED FIRE RETARDANT BIOCHEMICAL COMPOSITIONS FORMULATED USING ALKALI METAL SALTS, FREE FROM PHOSPHATES, NITRATES, AND AMMONIUM-SALTS, FOR NON-CORROSIVE AERIAL AND GROUND DELIVERY ONTO PROPERTY REQUIRING LONG-TERM PROTECTION AGAINST WILDFIRE | CA3, CA2, FIBP | CA4 20/4885CTSL 3632/4885CA2 2/4885 |
| US-20260069911-A1 | ENVIRONMENTALLY-CLEAN FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS AND POWDERS, AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD PRODUCTS | FGB, ACTB, FOSB | CA4 86/4885CTSL 933/4885CA2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.