Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14521213 | 1.00 | CHEK1 (0.61) | CHEK1FGFR1PLK4PLK1EGFR | |
| SCHEMBL6741475 | 1.00 | CHEK1 (0.61) | CHEK1FGFR1PLK4PLK1EGFR | |
| SCHEMBL6743609 | 0.87 | MDM2 (0.57) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL6743605 | 0.87 | MDM2 (0.57) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL14521214 | 0.87 | CHEK1 (0.61) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL14521211 | 0.83 | CHEK1 (0.56) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL4992390 | 0.83 | CHEK1 (0.67) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL4992383 | 0.83 | CHEK1 (0.67) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL14521215 | 0.82 | CHEK1 (0.58) | CHEK1FGFR1EGFRPDGFRBKDR | |
| SCHEMBL14521212 | 0.81 | CHEK1 (0.53) | CHEK1FGFR1EGFRPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |