Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.53 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.53 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743609 | 1.00 | MDM2 (0.57) | MDM2ARCHEK1CHEK2TUBB4A | |
| SCHEMBL6741475 | 0.87 | CHEK1 (0.61) | MDM2CHEK1CHEK2TUBB4ATUBB | |
| SCHEMBL14521213 | 0.87 | CHEK1 (0.61) | MDM2CHEK1CHEK2TUBB4ATUBB | |
| SCHEMBL6741471 | 0.87 | CHEK1 (0.61) | MDM2CHEK1CHEK2TUBB4ATUBB | |
| SCHEMBL3284774 | 0.84 | FLT3 (0.68) | MDM2TLK2PDGFRBKDRAURKB | |
| SCHEMBL3284812 | 0.84 | FLT3 (0.68) | MDM2TLK2PDGFRBKDRAURKB | |
| SCHEMBL3284777 | 0.84 | FLT3 (0.68) | MDM2TLK2PDGFRBKDRAURKB | |
| SCHEMBL14521214 | 0.78 | CHEK1 (0.61) | MDM2CHEK1TUBB4ATUBBTUBA3C | |
| SCHEMBL3283722 | 0.77 | MDM2 (0.72) | MDM2CHEK1CHEK2TLK2PDGFRB | |
| SCHEMBL3283723 | 0.77 | MDM2 (0.72) | MDM2CHEK1CHEK2TLK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |