Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.79 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.79 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.79 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.79 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.79 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.79 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.74 |
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 5/20 | 0.58 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | ARAF | P10398 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742363 | 1.00 | LRRK2 (0.79) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5468785 | 0.92 | LRRK2 (0.72) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5468784 | 0.92 | LRRK2 (0.72) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1395354 | 0.89 | LRRK2 (1.00) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1395352 | 0.89 | LRRK2 (1.00) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3800644 | 0.89 | LRRK2 (1.00) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5367163 | 0.87 | RAF1 (0.79) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5367313 | 0.85 | LRRK2 (0.56) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6694978 | 0.83 | ERBB2 (0.72) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1395329 | 0.83 | LRRK2 (0.79) | LRRK2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |