Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499681 | 0.85 | PIK3CA (0.73) | MTORPIK3CAPIK3R1HTTPIK3CG | |
| SCHEMBL1309097 | 0.85 | PIK3CA (1.00) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL1309370 | 0.81 | PIK3CA (0.71) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL6736048 | 0.81 | PIK3CA (0.66) | MTORPIK3CAPIK3R1HTTPIK3CG | |
| SCHEMBL4317272 | 0.80 | HTT (0.58) | MTORPIK3CAPIK3R1HTTPIK3CG | |
| SCHEMBL13761287 | 0.79 | HTT (0.61) | MTORPIK3CAPIK3R1HTTPIK3CG | |
| SCHEMBL1310041 | 0.79 | MTOR (0.69) | MTORPIK3CAPIK3R1HTTPIK3CG | |
| SCHEMBL32704 | 0.79 | MTOR (0.91) | MTORPIK3CAPIK3CG | |
| SCHEMBL6740369 | 0.79 | LMNA (0.78) | HTTTSHRMAPTLMNACYP1A2 | |
| SCHEMBL1309526 | 0.78 | PIK3CA (0.66) | MTORPIK3CAPIK3R1PIK3CGHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | CGI PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | claimed |
| WO-2004000820-A2 | CERTAIN AROMATIC MONOCYCLES AS KINASE MODULATORS | CELLULAR GENOMICS, INC. (US) | 2003-12-31 | — | — | WO | claimed |
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | CGI PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| WO-2004000820-A2 | CERTAIN AROMATIC MONOCYCLES AS KINASE MODULATORS | CELLULAR GENOMICS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082627-A1 | Certain aromatic monocycles as kinase modulators | MAP3K20, MAP3K1, MAP3K19 | MTOR 141/4885PIK3CA 249/4885PIK3R1 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.