Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743049 | 1.00 | CDK2 (0.45) | CDK2KDRERBB2DHFRRET | |
| SCHEMBL6744856 | 0.76 | ERBB2 (0.52) | KDRERBB2DHFRRETHPGD | |
| SCHEMBL6744854 | 0.76 | ERBB2 (0.52) | KDRERBB2DHFRRETHPGD | |
| SCHEMBL6389505 | 0.76 | ERBB2 (0.64) | ERBB2EGFR | |
| SCHEMBL6389512 | 0.76 | ERBB2 (0.64) | ERBB2EGFR | |
| SCHEMBL6395391 | 0.73 | NOX4 (0.58) | KDRERBB2RET | |
| SCHEMBL6395394 | 0.73 | NOX4 (0.58) | KDRERBB2RET | |
| SCHEMBL6745353 | 0.72 | CHEK1 (0.46) | KDRERBB2DHFRRETCSNK1D | |
| SCHEMBL6745348 | 0.72 | CHEK1 (0.46) | KDRERBB2DHFRRETCSNK1D | |
| SCHEMBL6742678 | 0.72 | CDK2 (0.53) | CDK2KDRERBB2RETEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |