Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | GFER | P55789 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15606404 | 0.83 | GAA (0.71) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL17394225 | 0.82 | GAA (0.69) | GAAMAPT | |
| SCHEMBL15606398 | 0.81 | GAA (0.68) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL12864572 | 0.81 | GAA (0.68) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL31272020 | 0.80 | GAA (1.00) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL6744037 | 0.80 | GAA (1.00) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL31271944 | 0.79 | GAA (0.69) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL18856668 | 0.78 | GAA (0.63) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL18856735 | 0.78 | GAA (0.63) | GAAMAPTGFERMEN1KMT2A | |
| SCHEMBL28159939 | 0.78 | MAPT (0.63) | GAAMAPTGFERJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870143-B1 | TRIAZOLE COMPOUNDS AS ANTIVIRALS | HOFFMANN LA ROCHE (CH) | 2017-05-17 | — | — | EP | disclosed |
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20140010783-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2014-01-09 | — | — | US | disclosed |
| US-20140010783-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2014-01-09 | — | — | US | disclosed |
| US-7317031-B2 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317031-B2 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| CN-100357278-C | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO MCNEIL PHARM INC (US) | 2007-12-26 | — | — | CN | disclosed |
| CN-1575284-A | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO MCNEIL PHARM INC (US) | 2005-02-02 | — | — | CN | disclosed |
| US-20040077699-A1 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | GAA 88/4885MAPT 4508/4885GFER 3631/4885 |
| US-20040077699-A1 | Substituted triazole diamine derivatives as kinase inhibitors | MAP2K2, PRKDC, MAP2K3 | GAA 2029/4885MAPT 1570/4885GFER 4650/4885 |
| US-20140010783-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | GAA 88/4885MAPT 4508/4885GFER 3631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.