⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540135 | 1.00 | — | — | |
| SCHEMBL23539581 | 0.83 | HSD17B10 (0.38) | — | |
| SCHEMBL23540666 | 0.83 | HSD17B10 (0.38) | — | |
| SCHEMBL29654500 | 0.81 | — | — | |
| SCHEMBL55052 | 0.81 | — | — | |
| SCHEMBL25329424 | 0.79 | — | — | |
| SCHEMBL23541057 | 0.79 | — | — | |
| SCHEMBL11221265 | 0.77 | LMNA (0.43) | — | |
| SCHEMBL9243054 | 0.76 | — | — | |
| SCHEMBL4888402 | 0.75 | LMNA (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987250-A | Synthesis of hydroxy sulfonic acids | UNION OIL COMPANY OF CALIFORNIA (US) | 1991-01-22 | — | — | US | claimed |
| US-4910330-A | Synthesis of sulfonic acids and carboxylic acid ester derivatives thereof | UNION OIL COMPANY OF CALIFORNIA (US) | 1990-03-20 | — | — | US | claimed |
| EP-4347603-A1 | SULFUR-CONTAINING HETEROAROMATIC TRICYCLIC KRAS INHIBITORS | Erasca, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022251296-A1 | SULFUR-CONTAINING HETEROAROMATIC TRICYCLIC KRAS INHIBITORS | ERASCA, INC. (US) | 2022-12-01 | — | — | WO | disclosed |
| US-20170183373-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYERMASE | MERCK SHARP & DOHME CORP. (US) | 2017-06-29 | — | — | US | disclosed |
| US-20140309412-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | IONIS PHARMACEUTICALS, INC. | 2014-10-16 | — | — | US | disclosed |
| WO-2014037833-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT INFLAMMATION AND LIPID DISORDERS | KANDULA, MAHESH (IN) | 2014-03-13 | — | — | WO | disclosed |
| US-8183216-B2 | Nucleoside derivatives as inhibitors of viral polymerases | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2012-05-22 | — | — | US | disclosed |
| US-20100210581-A1 | Nucleoside Derivatives as Inhibitors of Viral Polymerases | Istitute de Ricerche di Biologia Molecolare P. Angeletti (IT) | 2010-08-19 | — | — | US | disclosed |
| US-7323449-B2 | Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | MERCK & CO., INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-7323453-B2 | Methods of inhibiting orthopoxvirus replication with nucleoside compounds | MERCK & CO., INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-20070275912-A1 | Nucleoside derivatives as inhibitors of rna-dependent RNA viral polymerase | MERCK SHARP & DOHME CORP. | 2007-11-29 | — | — | US | disclosed |
| US-7202224-B2 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20070004669-A1 | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | CARROLL STEVEN S | 2007-01-04 | — | — | US | disclosed |
| US-4987250-A | Synthesis of hydroxy sulfonic acids | UNION OIL COMPANY OF CALIFORNIA (US) | 1991-01-22 | — | — | US | disclosed |
| US-4910330-A | Synthesis of sulfonic acids and carboxylic acid ester derivatives thereof | UNION OIL COMPANY OF CALIFORNIA (US) | 1990-03-20 | — | — | US | disclosed |
| US-4001310-A | POLYETHERS HAVING OXIDIZED THIOETHER SIDE CHAINS | THE DOW CHEMICAL COMPANY (US) | 1977-01-04 | — | — | US | disclosed |