Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411154 | 0.85 | MEN1 (0.53) | KMT2AMEN1POLBALDH1A1SYK | |
| SCHEMBL19129648 | 0.84 | MEN1 (0.57) | KMT2AMEN1POLBTSHRALDH1A1 | |
| SCHEMBL5692621 | 0.84 | POLB (0.56) | KMT2AMEN1POLBTSHRALDH1A1 | |
| SCHEMBL29570200 | 0.82 | ALDH1A1 (0.65) | KMT2ATSHRALDH1A1MAPTHTT | |
| SCHEMBL4048998 | 0.82 | ALDH1A1 (0.65) | KMT2ATSHRALDH1A1MAPTHTT | |
| SCHEMBL4056455 | 0.82 | ALDH1A1 (0.59) | KMT2ATSHRALDH1A1MAPTHTT | |
| SCHEMBL12290760 | 0.82 | MEN1 (0.56) | KMT2AMEN1POLBTSHRDRD1 | |
| SCHEMBL6740319 | 0.82 | ALDH1A1 (0.47) | KMT2AMEN1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL5692356 | 0.81 | ALDH1A1 (0.64) | KMT2ATSHRALDH1A1MAPTHTT | |
| SCHEMBL5692306 | 0.81 | ALDH1A1 (0.51) | POLBTSHRALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |