Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 6/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746250 | 0.91 | FEN1 (0.39) | KIF11FEN1ALOX5APPTGS2PTGS1 | |
| SCHEMBL6730163 | 0.88 | PTGS1 (0.40) | KIF11FEN1ALOX5APKMOPTGS2 | |
| SCHEMBL6744631 | 0.88 | PTGS2 (0.49) | FEN1ALOX5APKMOPTGS2PTGS1 | |
| SCHEMBL6747442 | 0.88 | PTGS2 (0.49) | FEN1ALOX5APKMOPTGS2PTGS1 | |
| SCHEMBL6746864 | 0.86 | FEN1 (0.42) | FEN1ALOX5APKMOPTGS2PTGS1 | |
| SCHEMBL6744191 | 0.85 | FEN1 (0.40) | FEN1ALOX5APKMOPTGS2PTGS1 | |
| SCHEMBL6836570 | 0.85 | LRRK2 (0.40) | KIF11PTGS2PTGS1CA12CA1 | |
| SCHEMBL6742763 | 0.84 | PTGS2 (0.52) | FEN1ALOX5APKMOPTGS2PTGS1 | |
| SCHEMBL6746002 | 0.84 | PTGS2 (0.41) | FEN1ALOX5APKMOPTGS2PTGS1 | |
| SCHEMBL6746750 | 0.83 | FEN1 (0.40) | FEN1ALOX5APKMOPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |