Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | TGM2 | P21980 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744081 | 1.00 | GSK3B (0.57) | GSK3BCDK2KDRTGM2RET | |
| SCHEMBL6740554 | 0.85 | CDK2 (0.50) | GSK3BCDK2KDRTGM2RET | |
| SCHEMBL6740553 | 0.85 | CDK2 (0.50) | GSK3BCDK2KDRTGM2RET | |
| SCHEMBL6742680 | 0.76 | CDK2 (0.53) | CDK2KDRRETEGFRPDGFRB | |
| SCHEMBL6742678 | 0.76 | CDK2 (0.53) | CDK2KDRRETEGFRPDGFRB | |
| SCHEMBL6743630 | 0.75 | CDK2 (0.48) | CDK2KDRTGM2RETPDPK1 | |
| SCHEMBL6743633 | 0.75 | CDK2 (0.48) | CDK2KDRTGM2RETPDPK1 | |
| SCHEMBL13036886 | 0.74 | GSK3B (1.00) | GSK3BKDRRETPDPK1PDGFRB | |
| SCHEMBL11748696 | 0.74 | GSK3B (1.00) | GSK3BKDRRETPDPK1PDGFRB | |
| SCHEMBL11748686 | 0.74 | GSK3B (1.00) | GSK3BKDRRETPDPK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |