Acetic Acid

Acetic Acid

SCHEMBL6744109

C=CC(=O)OCC(CC)CCCC.CC(=O)O.CCCCCCCCOC(=O)C=CC(=O)OCCCCCCCC

nearest known ligand 0.72

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.72
HCAR2 Q8TDS4 4/20 0.54
HPGD P15428 1/20 0.51
CYP3A4 P08684 3/20 0.47
ALDH1A1 P00352 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
ATM Q13315 2/20 0.46
PRSS1 P07477 1/20 0.42
PRSS2 P07478 1/20 0.42
PRSS3 P35030 1/20 0.42
CA2 P00918 1/20 0.41
RECQL P46063 1/20 0.40
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
RAB9A P51151 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7578944 0.96 TSHR (0.78) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL7958163 0.94 TSHR (0.83) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL6600454 0.94 TSHR (0.83) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL7627062 0.94 TSHR (0.83) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL8640150 0.94 TSHR (0.83) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL3401565 0.94 TSHR (0.83) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL5993716 0.94 TSHR (0.83) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL17139830 0.92 TSHR (0.81) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL8213029 0.92 TSHR (0.85) TSHRHCAR2HPGDCYP3A4ALDH1A1
SCHEMBL6746745 0.91 TSHR (0.66) TSHRHCAR2HPGDCYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6689460-B2 CARRIER SHEET WITH A PRESSURE-SENSITIVE ADHESIVE THEREON; AND AN AQUEOUS DISPERSION PRIMER TO PROMOTE ADHESION BETWEEN A CONSTRUCTION SURFACE AND THE MEMBRANE COMPOSED OF AN INTERPOLYMER OF A VINYL ACETATE, A MALEATE AND/OR AN ACRYLATE W. R. GRACE & CO.-CONN. 2004-02-10 US disclosed
US-20030003314-A1 Primer/membrane barrier system VERIFI LLC 2003-01-02 US disclosed