Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TYMS | P04818 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450940 | 0.77 | TYMS (0.53) | MAPTRAB9ATYMS | |
| SCHEMBL6449026 | 0.76 | TYMS (0.57) | TYMS | |
| SCHEMBL6744219 | 0.71 | MAPT (0.46) | MAPTSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL23882597 | 0.70 | RAB9A (0.78) | MAPTSMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL5162135 | 0.69 | MAPT (0.68) | MAPTSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL6653100 | 0.67 | TYMS (1.00) | MAPTSMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL6652840 | 0.65 | TYMS (0.59) | MAPTSMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL30589037 | 0.65 | TYMS (1.00) | TYMS | |
| SCHEMBL6654365 | 0.65 | TYMS (1.00) | TYMS | |
| SCHEMBL32666088 | 0.65 | KDM4E (0.63) | MAPTSMN1; SMN2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040057990-A1 | Liposomal benzoquinazoline thymidylate synthase inhibitor formulations | OSI PHARMACEUTICALS, INC. | 2004-03-25 | — | — | US | disclosed |
| US-6689381-B2 | LIPOSOME COMPRISING PHOSPHATIDYLCHOLINE, CHOLESTEROL, AS WELL AS BENZOQUINAZOLINE THYMIDYLATE SYNTHASE INHIBITOR; IMPROVED PHARMACOKINETICS AND EFFICACY AS ANTI-TUMOR AGENTS COMPARED TO FREE DRUG | OSI PHARMACEUTICALS, INC. | 2004-02-10 | — | — | US | disclosed |
| US-20020034538-A1 | Liposomal benzoquinazolne thymidylate synthase inhibitor formulations | GILEAD SCIENCES, INC. | 2002-03-21 | — | — | US | disclosed |
| US-5663337-A | ENZYME, ANTITUMOR | GLAXO WELLCOME INC. (US) | 1997-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020034538-A1 | Liposomal benzoquinazolne thymidylate synthase inhibitor formulations | TYMS, TYMP, CTPS1 | MAPT 1747/4885SMN1; SMN2 4158/4885NPC1 87/4885 |
| US-20040057990-A1 | Liposomal benzoquinazoline thymidylate synthase inhibitor formulations | TYMS, TYMP, CTPS1 | MAPT 1712/4885SMN1; SMN2 4201/4885NPC1 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.