Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381342 | 0.83 | ALDH1A1 (0.79) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL10933724 | 0.83 | ALDH1A1 (0.65) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL311267 | 0.83 | ALDH1A1 (0.79) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL9506749 | 0.81 | ALDH1A1 (0.63) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL18143522 | 0.79 | ALDH1A1 (1.00) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL27188 | 0.79 | ALDH1A1 (1.00) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL25865319 | 0.77 | PPARG (0.47) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL9617636 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL6834819 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A | |
| SCHEMBL2905368 | 0.75 | ALDH1A1 (0.68) | ALDH1A1HPGDCYP3A4HSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689808-B2 | TREATING OR PREVENTING EPILEPSY OR NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2004-02-10 | — | — | US | claimed |
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-11-27 | — | — | US | claimed |
| EP-1320528-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-06-25 | — | — | EP | claimed |
| WO-2002000638-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | INSTITUTE OF MATERIA MEDICA (CN) | 2002-01-03 | — | — | WO | claimed |
| US-6689808-B2 | TREATING OR PREVENTING EPILEPSY OR NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2004-02-10 | — | — | US | disclosed |
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-11-27 | — | — | US | disclosed |
| EP-1320528-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002000638-A2 | SUBSTITUTED PHTHALIDES AS ANTI-CONVULSIVE DRUGS | INSTITUTE OF MATERIA MEDICA (CN) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220393-A1 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them | NR5A2, NR2E3, NR4A1 | ALDH1A1 1151/4885HPGD 1998/4885CYP3A4 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.