SCHEMBL6744872

SCHEMBL6744872

COc1ccc(-c2oc3cc(OC)ccc3c2Cc2ccc(OCCN(C)C)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.52
BCHE P06276 4/20 0.45
ACHE P22303 3/20 0.45
LTA4H P09960 1/20 0.45
SIGMAR1 Q99720 1/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
TP53 P04637 1/20 0.45
CYP3A4 P08684 1/20 0.45
MAPT P10636 1/20 0.45
HPGD P15428 1/20 0.45
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CYP19A1 P11511 1/20 0.44
CNR1 P21554 1/20 0.43
CNR2 P34972 1/20 0.43
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6744836 0.99 ESR1 (0.51) ESR1BCHEACHELTA4HSIGMAR1
SCHEMBL6749880 0.89 BCHE (0.59) ESR1BCHEACHELTA4HMEN1
Hydrochloric Acid SCHEMBL6749922 0.89 BCHE (0.58) ESR1BCHEACHELTA4HMEN1
SCHEMBL6746958 0.89 LTA4H (0.48) ESR1BCHEACHELTA4HMEN1
Hydrochloric Acid SCHEMBL6748796 0.88 LTA4H (0.47) ESR1BCHEACHELTA4HMEN1
SCHEMBL7117571 0.87 MEN1 (0.56) ESR1MEN1KMT2AKDM4EALDH1A1
SCHEMBL6745462 0.81 ESR1 (0.61) ESR1BCHEACHELTA4H
Hydrochloric Acid SCHEMBL6751621 0.80 ESR1 (0.60) ESR1BCHEACHELTA4H
SCHEMBL4653103 0.79 CNR1 (0.67) ESR1BCHEACHECYP3A4MAPT
SCHEMBL6751622 0.78 MAPT (0.41) ESR1BCHEACHEMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6703407-B1 TREATMENT OF MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION ELI LILLY AND COMPANY 2004-03-09 US disclosed
EP-0774966-B1 BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS LILLY CO ELI (US) 2003-11-05 EP disclosed
US-6407243-B1 POSTMEMOPAUSE DISEASES ELI LILLY AND COMPANY 2002-06-18 US disclosed
EP-0774966-A4 BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS LILLY CO ELI (US) 1998-01-07 EP disclosed
EP-0774966-A1 BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS ELI LILLY AND COMPANY (US) 1997-05-28 EP disclosed
WO-1996009040-A1 BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS ELI LILLY AND COMPANY (US) 1996-03-28 WO disclosed