Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.40 |
| ▸ | HTR2A | P28223 | 10/20 | 0.40 |
| ▸ | HTR2B | P41595 | 9/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732591 | 1.00 | HTR2C (0.40) | HTR2CHTR2AHTR2BMAOAMAOB | |
| SCHEMBL6746064 | 1.00 | HTR2C (0.40) | HTR2CHTR2AHTR2BMAOAMAOB | |
| SCHEMBL6748708 | 1.00 | HTR2C (0.40) | HTR2CHTR2AHTR2BMAOAMAOB | |
| SCHEMBL13621770 | 1.00 | HTR2C (0.40) | HTR2CHTR2AHTR2BMAOAMAOB | |
| Hydrochloric Acid SCHEMBL6747587 | 0.98 | HTR2C (0.42) | HTR2CHTR2AHTR2BMAOAMAOB | |
| Hydrochloric Acid SCHEMBL6747588 | 0.98 | HTR2C (0.42) | HTR2CHTR2AHTR2BMAOAMAOB | |
| SCHEMBL27623196 | 0.83 | MAOA (0.37) | HTR2CHTR2AMAOAMAOBSLC6A2 | |
| SCHEMBL25372050 | 0.80 | POLB (0.36) | MAOAMAOBMEN1KMT2A | |
| SCHEMBL27531884 | 0.79 | HTT (0.43) | SLC6A2HTR1AADRA2ADRD1TBXA2R | |
| SCHEMBL25369666 | 0.78 | GRM2 (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6812353-B2 | INTERMEDIATES FOR CENTRAL NERVOUS SYSTEM MEDICATIONS; PRIMARY AMINE FUNCTIONALITY | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2004-11-02 | — | — | US | disclosed |
| US-20040092579-A1 | Central nervous system diosrders; catalytic hydrogenation | MERCK GMBH (DE) | 2004-05-13 | — | — | US | disclosed |
| EP-1317438-A1 | CHROMANONE DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020507-A1 | CHROMANONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092579-A1 | Central nervous system diosrders; catalytic hydrogenation | CBR3, CBR1, HCRTR1 | HTR2C 171/4885HTR2A 542/4885HTR2B 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.