Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.39 |
| ▸ | CA2 | P00918 | 8/20 | 0.39 |
| ▸ | FEN1 | P39748 | 8/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.35 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746036 | 0.91 | FEN1 (0.40) | CA1CA2FEN1ALOX5APMAPK1 | |
| SCHEMBL6746267 | 0.90 | FEN1 (0.44) | CA1CA2FEN1ALOX5AP | |
| SCHEMBL6746459 | 0.88 | CA1 (0.40) | CA1CA2FEN1ALOX5APTDP2 | |
| SCHEMBL6749997 | 0.87 | FEN1 (0.43) | CA1CA2FEN1ALOX5APTDP2 | |
| SCHEMBL6750040 | 0.86 | PTGS2 (0.46) | CA1CA2FEN1ALOX5APCTSL | |
| SCHEMBL6744782 | 0.85 | CA1 (0.39) | CA1CA2FEN1ALOX5AP | |
| SCHEMBL6744898 | 0.85 | CA1 (0.41) | CA1CA2FEN1ALOX5APCDC25B | |
| SCHEMBL6723662 | 0.85 | FEN1 (0.41) | CA1CA2FEN1ALOX5APCDC25B | |
| SCHEMBL6749919 | 0.85 | PTGS2 (0.47) | CA1CA2FEN1ALOX5APCA9 | |
| SCHEMBL6749461 | 0.84 | FEN1 (0.47) | CA1CA2FEN1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |