⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885477 | 0.75 | FDPS (0.32) | — | |
| SCHEMBL24112092 | 0.74 | — | — | |
| SCHEMBL22914823 | 0.74 | — | — | |
| SCHEMBL7346608 | 0.73 | — | — | |
| SCHEMBL165217 | 0.71 | — | — | |
| SCHEMBL6649357 | 0.71 | — | — | |
| SCHEMBL7867293 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL28509554 | 0.69 | — | — | |
| SCHEMBL11118463 | 0.69 | FDPS (0.30) | — | |
| SCHEMBL13281659 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747039-B2 | INHIBITING CELL PROLIFERATION IN MAMMALS | ALBANY MOLECULAR RESEARCH, INC. | 2004-06-08 | — | — | US | disclosed |
| US-20030225069-A1 | Aza-benzothiopyranoindazoles with antitumor activity | BARCLAYS BANK PLC, AS THE COLLATERAL AGENT | 2003-12-04 | — | — | US | disclosed |
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | disclosed |
| CN-1051549-C | 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6(2h)-ones | UNIV VERMONT (US) | 2000-04-19 | — | — | CN | disclosed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5519029-A | ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |
| EP-0662076-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1995-07-12 | — | — | EP | disclosed |
| CN-1101046-A | 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6(2h)-ones | UNIV VERMONT (US) | 1995-04-05 | — | — | CN | disclosed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | disclosed |
| EP-0170412-B1 | Benzoselenino[4,3,2-cd]indazole compounds, compositions comprising the compounds and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0114002-B1 | BENZOTHIOPYRANO(4,3,2,-CD)INDAZOLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0170412-A1 | Benzoselenino[4,3,2-cd]indazole compounds, compositions comprising the compounds and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-05 | — | — | EP | disclosed |
| EP-0114002-A2 | Benzothiopyrano(4,3,2,-cd)indazoles, their pharmaceutical compositions and methods for their production | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |