Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367281 | 0.87 | KMT2A (0.62) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6038507 | 0.87 | KMT2A (0.52) | TSHRALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL16235349 | 0.78 | TSHR (1.00) | TSHRALDH1A1POLBLMNAKDM4E | |
| SCHEMBL6751910 | 0.77 | PTGDR2 (0.57) | TSHRALDH1A1POLBLMNAKDM4E | |
| Hydrochloric Acid SCHEMBL491745 | 0.76 | TSHR (0.67) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6751907 | 0.75 | TSHR (0.51) | TSHRALDH1A1POLBLMNAKDM4E | |
| SCHEMBL6038819 | 0.74 | HTT (0.55) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL2450795 | 0.74 | PTGDR2 (0.66) | TSHRHTTPTGDR2 | |
| SCHEMBL491744 | 0.74 | TSHR (0.68) | TSHRALDH1A1POLBLMNAKDM4E | |
| SCHEMBL492321 | 0.74 | TSHR (0.68) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058265-A1 | COMPOUND LIBRARIES OF 2,3-SUBSTITUTED PYRAZINE DERIVATIVES CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS | BIOFOCUS PLC (GB) | 2004-07-15 | — | — | WO | disclosed |