Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617658 | 0.82 | BRPF1 (0.43) | BRPF1CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL4054875 | 0.79 | KDM4E (0.53) | AKR1C3AKR1C2TUBB1CCR2KDM4E | |
| SCHEMBL19211743 | 0.79 | MCL1 (0.53) | AKR1C3AKR1C2TUBB1KDM4EMEN1 | |
| SCHEMBL27551332 | 0.79 | AKR1C3 (0.52) | AKR1C3AKR1C2CCR2MEN1KMT2A | |
| SCHEMBL6479624 | 0.79 | BRPF1 (0.43) | BRPF1CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL5107559 | 0.79 | P2RX4 (0.41) | BRPF1CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL5436506 | 0.79 | NR1H2 (0.44) | BRPF1CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL30343692 | 0.77 | MCL1 (0.49) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5967722 | 0.77 | MCL1 (0.49) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6253573 | 0.76 | BRPF1 (0.41) | BRPF1CHEK1AURKADAPK3CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946405-A | Use of 9h-purine-2,6-diamine derivatives in the treatment of proliferative diseases and novel 9h-purine-2,6-diamine derivatives | NOVARTIS AG (CH) | 2007-04-11 | — | — | CN | claimed |
| CN-1946405-B | Use of 9h-purine-2,6-diamine derivatives in the treatment of proliferative diseases and novel 9h-purine-2,6-diamine derivatives | NOVARTIS AG | 2010-10-13 | — | — | CN | disclosed |
| CN-1946405-A | Use of 9h-purine-2,6-diamine derivatives in the treatment of proliferative diseases and novel 9h-purine-2,6-diamine derivatives | NOVARTIS AG (CH) | 2007-04-11 | — | — | CN | disclosed |
| US-20040019065-A1 | Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use | ROMINES WILLIAM HENRY (US) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019065-A1 | Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use | CDKN1A, CCNA1, TYMP | BRPF1 1746/4885CHEK1 195/4885AURKA 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.