Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413324 | 0.89 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1MEN1KMT2AL3MBTL1 | |
| SCHEMBL5320378 | 0.87 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1MEN1KMT2AL3MBTL1 | |
| SCHEMBL5321619 | 0.87 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1MEN1KMT2AL3MBTL1 | |
| SCHEMBL1388381 | 0.84 | DYRK1A (0.66) | MEN1KMT2AL3MBTL1MAPTKDM4E | |
| SCHEMBL2175274 | 0.84 | MEN1 (0.72) | MEN1KMT2AL3MBTL1MAPTKDM4E | |
| SCHEMBL14413318 | 0.83 | HDAC1 (0.48) | HSP90AA1HSP90AB1MEN1KMT2AMAPT | |
| SCHEMBL10686590 | 0.83 | MEN1 (0.57) | MEN1KMT2AL3MBTL1MAPTKDM4E | |
| SCHEMBL4502579 | 0.83 | KDM4E (0.68) | MEN1KMT2AL3MBTL1MAPTKDM4E | |
| SCHEMBL14413004 | 0.81 | DHFR (0.49) | HSP90AA1HSP90AB1KDM4EMAOB | |
| SCHEMBL1644753 | 0.81 | DYRK1A (0.71) | HSP90AA1HSP90AB1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098835-A1 | AMINO PYRYMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-07 | — | — | WO | disclosed |
| US-20040072770-A1 | Methods for specifically inhibiting histone deacetylase-7 and 8 | METHYLGENE, INC. (CA) | 2004-04-15 | — | — | US | disclosed |
| WO-2004005513-A2 | METHODS FOR SPECIFICALLY INHIBITING HISTONE DEACETYLASE-7 AND 8 | METHYLGENE, INC. (CA) | 2004-01-15 | — | — | WO | disclosed |
| WO-2004005513-A2 | METHODS FOR SPECIFICALLY INHIBITING HISTONE DEACETYLASE-7 AND 8 | METHYLGENE, INC. (CA) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072770-A1 | Methods for specifically inhibiting histone deacetylase-7 and 8 | HDAC8, HDAC7, HDAC1 | HSP90AA1 318/4885HSP90AB1 274/4885MEN1 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.