Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.39 |
| ▸ | FEN1 | P39748 | 10/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6745117 | 0.92 | ALOX5AP (0.40) | ALOX5APFEN1NR1H2NR1H3PTGS2 | |
| SCHEMBL6730163 | 0.88 | PTGS1 (0.40) | ALOX5APFEN1NR1H2NR1H3PTGS2 | |
| SCHEMBL6747322 | 0.88 | PTGS2 (0.50) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6742739 | 0.88 | PTGS2 (0.50) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6746038 | 0.86 | ALOX5AP (0.41) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6745215 | 0.86 | FEN1 (0.45) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6840854 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1KIF11LRRK2 | |
| SCHEMBL6749686 | 0.85 | PTGS2 (0.53) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6747090 | 0.85 | PTGS2 (0.42) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6746256 | 0.84 | ALOX5AP (0.41) | ALOX5APFEN1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |