Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.54 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6751611 | 0.90 | ESR1 (0.66) | ESR1ESR2F2 | |
| SCHEMBL6748810 | 0.90 | ESR1 (0.63) | ESR1ESR2F2 | |
| SCHEMBL6744378 | 0.87 | ESR1 (0.58) | ESR1ESR2F2 | |
| Hydrochloric Acid SCHEMBL6749894 | 0.86 | ESR1 (0.59) | ESR1ESR2F2 | |
| SCHEMBL7118975 | 0.82 | ESR1 (0.54) | ESR1ESR2 | |
| SCHEMBL6745462 | 0.81 | ESR1 (0.61) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6751621 | 0.81 | ESR1 (0.60) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL6746982 | 0.81 | ESR1 (0.59) | ESR1ESR2F2 | |
| SCHEMBL14506973 | 0.79 | ESR1 (0.68) | ESR1ESR2 | |
| SCHEMBL6748780 | 0.78 | LTA4H (0.56) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703407-B1 | TREATMENT OF MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION | ELI LILLY AND COMPANY | 2004-03-09 | — | — | US | disclosed |
| EP-0774966-B1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6407243-B1 | POSTMEMOPAUSE DISEASES | ELI LILLY AND COMPANY | 2002-06-18 | — | — | US | disclosed |
| EP-0774966-A4 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0774966-A1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996009040-A1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |