Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6753818 | 0.90 | CDK2 (0.45) | KMT2AL3MBTL1CDK2CCNA2CCNE2 | |
| SCHEMBL6753817 | 0.90 | CDK2 (0.45) | KMT2AL3MBTL1CDK2CCNA2CCNE2 | |
| SCHEMBL6751476 | 0.86 | CCNE2 (0.48) | CDK2CCNA2CCNE2CCNE1CCNA1 | |
| SCHEMBL6751475 | 0.86 | CCNE2 (0.48) | CDK2CCNA2CCNE2CCNE1CCNA1 | |
| SCHEMBL4372507 | 0.83 | MERTK (0.39) | CDK2CCNA2JAK1FLT3BTK | |
| SCHEMBL4372504 | 0.83 | MERTK (0.39) | CDK2CCNA2JAK1FLT3BTK | |
| SCHEMBL4374864 | 0.80 | FLT3 (0.43) | KMT2AL3MBTL1CKS1BSKP1SKP2 | |
| SCHEMBL4374861 | 0.80 | FLT3 (0.43) | KMT2AL3MBTL1CKS1BSKP1SKP2 | |
| SCHEMBL4372753 | 0.70 | CDK2 (0.49) | CDK2CCNA2CCNE2CCNE1JAK1 | |
| SCHEMBL4372748 | 0.70 | CDK2 (0.49) | CDK2CCNA2CCNE2CCNE1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377579-A2 | ACYL AND SULFONYL DERIVATIVES OF 6,9-DISUBSTITUTED 2-(TRANS-1,4-DIAMINOCYCLOHEXYL)-PURINES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | Aventis Pharmaceuticals Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002042303-A2 | ACYL AND SULFONYL DERIVATIVES OF 6,9-DISUBSTITUTED 2-(TRANS-1,4-DIAMINOCYCLOHEXYL)-PURINES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | AVENTIS PHARMACEUTICALS INC. (US) | 2002-05-30 | — | — | WO | disclosed |