Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 20/20 | 0.58 |
| ▸ | MMP13 | P45452 | 19/20 | 0.58 |
| ▸ | MMP9 | P14780 | 3/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.58 |
| ▸ | MMP3 | P08254 | 2/20 | 0.58 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6756489 | 0.88 | CA12 (0.48) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6754058 | 0.88 | MMP1 (0.54) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL7079076 | 0.87 | MMP1 (0.45) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL5814098 | 0.85 | MMP1 (0.56) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6501396 | 0.83 | MMP1 (0.67) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6501047 | 0.82 | MMP1 (0.67) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6756495 | 0.81 | MMP1 (0.68) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6500975 | 0.81 | MMP1 (0.51) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6503573 | 0.79 | MMP1 (0.46) | MMP1ADAM17MMP13MMP9ADAM10 | |
| SCHEMBL6502767 | 0.78 | MMP1 (0.45) | MMP1ADAM17MMP13MMP9ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716833-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE AND DEGENERATIVE CARTILAGE LOSS. | WYETH HOLDINGS CORPORATION | 2004-04-06 | — | — | US | disclosed |