Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.57 |
| ▸ | MMP1 | P03956 | 15/20 | 0.57 |
| ▸ | MMP9 | P14780 | 15/20 | 0.57 |
| ▸ | MMP13 | P45452 | 14/20 | 0.57 |
| ▸ | MMP14 | P50281 | 4/20 | 0.48 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234022 | 0.94 | ADAM17 (0.59) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6501113 | 0.90 | ADAM17 (0.60) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL3938817 | 0.88 | ADAM17 (0.72) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6932556 | 0.88 | ADAM17 (0.72) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6530353 | 0.87 | ADAM17 (0.63) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6506054 | 0.84 | ADAM17 (0.62) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6507798 | 0.84 | ADAM17 (0.62) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6756491 | 0.84 | ADAM17 (0.52) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6630484 | 0.83 | ADAM17 (0.58) | ADAM17MMP1MMP9MMP13MMP14 | |
| SCHEMBL6650497 | 0.82 | ADAM17 (0.64) | ADAM17MMP1MMP9MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716833-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE AND DEGENERATIVE CARTILAGE LOSS. | WYETH HOLDINGS CORPORATION | 2004-04-06 | — | — | US | disclosed |