SCHEMBL6754252

SCHEMBL6754252

O=C(NC1CN2CCC1CC2)c1ccc2oc(C3CC3)nc2c1

nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 6/20 0.62
KCNH2 Q12809 1/20 0.62
CHRNA7 P36544 10/20 0.62
HTR3E A5X5Y0 4/20 0.62
HTR3B O95264 4/20 0.62
HTR3D Q70Z44 4/20 0.62
HTR3C Q8WXA8 4/20 0.62
CYP2D6 P10635 1/20 0.62
CHRNB4 P30926 2/20 0.59
CHRNA3 P32297 2/20 0.59
ALOX15 P16050 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6655021 1.00 HTR3A (0.62) HTR3AKCNH2CHRNA7HTR3EHTR3B
SCHEMBL6632761 0.92 HTR3A (0.62) HTR3AKCNH2CHRNA7HTR3EHTR3B
SCHEMBL5917828 0.86 CHRNA7 (0.67) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6656161 0.86 CHRNA7 (0.67) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6389995 0.81 CHRNA7 (0.63) HTR3AKCNH2CHRNA7HTR3EHTR3B
SCHEMBL6389988 0.81 CHRNA7 (0.63) HTR3AKCNH2CHRNA7HTR3EHTR3B
Fumaric Acid SCHEMBL6838869 0.81 CHRNA7 (0.60) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6843567 0.81 CHRNA7 (0.57) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6388998 0.81 CHRNA7 (0.66) HTR3ACHRNA7HTR3EHTR3BHTR3D
SCHEMBL6631572 0.79 CHRNA7 (0.48) HTR3AKCNH2CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404674-A2 QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS PHARMACIA & UPJOHN COMPANY (US) 2004-04-07 EP claimed
WO-2002100858-A2 QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS PHARMACIA & UPJOHN COMPANY (US) 2002-12-19 WO claimed