Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF20A | O95235 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754816 | 1.00 | KIF20A (0.46) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755586 | 0.90 | KIF20A (0.46) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755585 | 0.90 | KIF20A (0.46) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755629 | 0.87 | KDM4E (0.52) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755627 | 0.87 | KDM4E (0.52) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755476 | 0.81 | APP (0.63) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755562 | 0.77 | KDM4E (0.52) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755563 | 0.77 | KDM4E (0.52) | KIF20AALDH1A1MAPTPOLBAPP | |
| SCHEMBL6755673 | 0.77 | CHEK1 (0.58) | KIF20AALDH1A1MAPTPOLBNPC1 | |
| SCHEMBL6755674 | 0.77 | CHEK1 (0.58) | KIF20AALDH1A1MAPTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3507497-B2 | — | — | 2004-03-15 | — | — | JP | claimed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | claimed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | claimed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | claimed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | disclosed |
| US-5397787-A | Tyrosine kinase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-03-14 | — | — | US | disclosed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | disclosed |