Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 4/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482417 | 0.77 | CYP1A2 (0.49) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL6761028 | 0.76 | L3MBTL1 (0.35) | KDM4EPOLBMAPT | |
| SCHEMBL6756990 | 0.75 | KCNA5 (0.49) | BRD4TDP2KDM4EMAPTHTT | |
| SCHEMBL14895436 | 0.74 | BRD4 (0.55) | BRD4TDP2KDM4ECASP1HSD17B10 | |
| SCHEMBL25780927 | 0.73 | BRD4 (0.56) | BRD4TDP2GABRA2GABRB2KDM4E | |
| SCHEMBL25780703 | 0.72 | BRD4 (0.58) | BRD4TDP2GABRG2GABRB3GABRA5 | |
| SCHEMBL498660 | 0.72 | MYC (0.42) | KDM4EHSD17B10MAPTMAPK1 | |
| SCHEMBL4906896 | 0.69 | BRD4 (0.70) | BRD4TDP2MAPTHTT | |
| SCHEMBL29479606 | 0.69 | BRD4 (0.51) | BRD4TDP2GABRG2GABRB3GABRA5 | |
| SCHEMBL27911015 | 0.69 | KMT2A (0.43) | KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794377-B2 | ORTHO, ORTHO-SUBSTITUTED NITROGEN-CONTAINING BISARYL COMPOUNDS, USEFUL FOR THE TREATMENT AND PROPHYLAXIS OF ATRIAL ARRHYMIAS, E.G. ATRAIL FIBRILLATION OR ATRIAL FLUTTERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-09-21 | — | — | US | disclosed |
| US-20030060470-A1 | Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060470-A1 | Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them | OXER1, PON1, CYP2C9 | BRD4 2100/4885TDP2 3041/4885GABRG2 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.