SCHEMBL6757146

SCHEMBL6757146

NC(=O)/C=C1/CCc2c(Cl)cc(F)cc21

nearest known ligand 0.73

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.73
MAOB P27338 1/20 0.73
LOX P28300 1/20 0.73
NOTUM Q6P988 3/20 0.46
HTR5A P47898 1/20 0.34
IDO1 P14902 1/20 0.32
GRM2 Q14416 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6757144 1.00 MAOA (0.73) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL6757148 1.00 MAOA (0.73) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL8361250 0.86 MAOA (0.54) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL8359381 0.86 MAOA (0.54) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL8359378 0.86 MAOA (0.54) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL8359374 0.86 MAOA (0.54) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL8361249 0.86 MAOA (0.54) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL8361252 0.86 MAOA (0.54) MAOAMAOBLOXNOTUMHTR5A
SCHEMBL6760231 0.84 MAOA (0.55) MAOAMAOBLOXNOTUM
SCHEMBL6760228 0.84 MAOA (0.55) MAOAMAOBLOXNOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0759026-B1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE WELLCOME FOUND (GB) 1999-08-18 EP claimed
US-5708033-A ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS OR ANALGESICS GLAXO WELLCOME INC. (US) 1998-01-13 US claimed
EP-0759026-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1997-02-26 EP claimed
WO-1995030645-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-16 WO claimed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO claimed
US-20040116405-A1 Use of bicyclic esters or amides for the treatment of diseases responsive to enhanced potassium channel activity GLAXO GROUP LIMITED (GB) 2004-06-17 US disclosed
EP-1358150-A1 USE OF BICYCLIC ESTERS OR AMIDES FOR THE TREATMENT OF DISEASES RESPONSIVE TO ENHANCED POTASSIUM CHANNEL ACTIVITY GLAXO GROUP LIMITED (GB) 2003-11-05 EP disclosed
WO-2002062745-A1 USE OF BICYCLIC ESTERS OR AMIDES FOR THE TREATMENT OF DISEASES RESPONSIVE TO ENHANCED POTASSIUM CHANNEL ACTIVITY GLAXO GROUP LIMITED (GB) 2002-08-15 WO disclosed
EP-0759026-B1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE WELLCOME FOUND (GB) 1999-08-18 EP disclosed
US-5708033-A ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS OR ANALGESICS GLAXO WELLCOME INC. (US) 1998-01-13 US disclosed
EP-0759026-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1997-02-26 EP disclosed
WO-1995030645-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-16 WO disclosed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO disclosed