Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31631301 | 0.87 | NPC1 (0.74) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL1738419 | 0.87 | NPC1 (0.74) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL1736587 | 0.86 | NPC1 (0.70) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL7832980 | 0.86 | NPC1 (0.70) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL9539135 | 0.86 | NPC1 (0.74) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL6837551 | 0.86 | NPC1 (0.70) | NPC1PKMMAPTRAB9ALMNA | |
| Methyl Alcohol SCHEMBL10640492 | 0.83 | NPC1 (0.70) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL9536527 | 0.83 | NPC1 (1.00) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL26922025 | 0.80 | NPC1 (0.62) | NPC1PKMMAPTRAB9ALMNA | |
| SCHEMBL31753053 | 0.80 | NPC1 (0.72) | NPC1PKMMAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034064-A1 | 2-(biarylalkyl)amino-3-(alkanoylamino)pyridine derivatives | KUDUK SCOTT D (US) | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034064-A1 | 2-(biarylalkyl)amino-3-(alkanoylamino)pyridine derivatives | BDKRB1, BDKRB2, LTB4R2 | NPC1 2046/4885PKM 1899/4885MAPT 3397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.